On a completely separate note, I’ve been considering trying microdosing semiglutides for a few months to see how it goes and am curious if anyone else has done so or has any thoughts on it here. I’m not interested in full doses because I can’t handle extreme nausea and other GI issues, but I’m curious if a microdose might reduce cravings, have sleep benefits, help with me PCOS and diabetes risk etc. I already do strength-training twice a week, which I hope would offset any muscle loss.
It's my estimation that... every man ever got a statue made of him, was one kind of sumbitch or another.
Mal ,'Jaynestown'
Natter 78: I might need to watch some Buffy for inspiration
Off-topic discussion. Wanna talk about corsets, duct tape, butt kicking, or physics? This is the place. Detailed discussion of any current-season TV must be whitefonted.
Pix - Apr 15, 2026 6:18:07 pm PDT #12329 of 12473
The status is NOT quo.
JenP - Apr 15, 2026 7:02:49 pm PDT #12330 of 12473
My personal experience was with Ozempic, and I can't say when in the dosing ramp up the food noise issue got better, but it wasn't right away. The effect disappeared when I went off of it.
I'm now on the Wegovy pill and did not notice anything at all on the lowest dose (no ill or positive effects), and I start the second month's ramp up dose tomorrow. Won't be at full dose until the fourth month.
I hadn't heard of microdosing GLP-1, but I also didn't suffer from nausea on the injectable or the pills (so far, anyway). But the low dose pill has not had any effect on the "craving" aspect, if that's a useful data point.
Pix - Apr 15, 2026 7:19:57 pm PDT #12331 of 12473
The status is NOT quo.
Thanks, Jen!
Laura - Apr 15, 2026 7:20:55 pm PDT #12332 of 12473
Our wings are not tired.
I switched from once a week to halving the dose for twice a week instead to lessen side effects. I was told you could divide the weekly dose into as many days as convenient. The only issue I have had is that I really can't eat at night unless I want to suffer. Overeating isn't an issue because often by the time I have prepared the food, I already have lost interest.
Laura - Apr 16, 2026 5:55:04 am PDT #12333 of 12473
Our wings are not tired.
Time to make some noise! Happiest birthday wishes to NoiseDesign! I hope the world treats you well today and may this year be filled with delightful surprises.
Shir - Apr 16, 2026 6:29:56 am PDT #12334 of 12473
"And that's why God Almighty gave us fire insurance and the public defender".
I'm sorry to hear about Trudy's mom. My condolences.
Shir - Apr 16, 2026 6:30:53 am PDT #12335 of 12473
"And that's why God Almighty gave us fire insurance and the public defender".
And on a separate note: ND, happy birthday!
JenP - Apr 16, 2026 6:42:00 am PDT #12336 of 12473
Happy, Happy Birthday, ND! May the year ahead hold much joy.
Matt the Bruins fan - Apr 16, 2026 6:52:09 am PDT #12337 of 12473
You have to remember that being a 5-time Olympic medalist means Hilary Knight has been playing hockey at an elite level at least 16 years. It's impossible for her to be a teenage girl less than 16 years old, thus the President's complete lack of interest.
Happy Birthday Noise Design!
lisah - Apr 16, 2026 9:11:58 am PDT #12338 of 12473
Punishingly Intricate
Happy birthday, ND!!!